Tuesday, February 23, 2021

Study: Severe forms of COVID-19 have a genetic predisposition


The study, published in the journal Frontiers in Immunology by the HSE team, attributed this susceptibility to a set of six molecules that contribute to T-cell immunity, “one of the key mechanisms used by the human body to fight viral infections.” ‘, transmits DPA, quoted by Agerpres.

Thus, according to the quoted source, these molecules, known as human leukocyte antigen class I (HLA-I), are “unique to each individual”, but whether or not they destroy the new coronavirus “is largely related to genetics”. ‘, as the molecules are inherited from parents.

“If a person has a set that is ineffective in such a detection, it is probably a more severe case of the disease,” said the research team.

And the findings were based on the analysis of genotype samples from both COVID-19 patients in Moscow and Madrid, along with a control group of samples from healthy people.

The source also said that these results of the study come in the context of fears that virus mutations reported in the UK and South Africa could lead to more severe forms of the disease and prove resistant to the vaccine, although scientists asked by Nature magazine last week said the virus would become less lethal over time.

At the same time, the Sputnik V vaccine – in which Russia has been accused of lack of transparency – is 91.6% effective against symptomatic forms of COVID-19, according to results published Tuesday in the medical journal The Lancet and validated by independent experts.

Several voices have begun to rise in Europe in recent weeks for the European Medicines Agency (EMA) to quickly evaluate Sputnik V, which is already used in Russia and several countries – including Argentina and Algeria.

The results published in The Lancet come from the latest stage of clinical trials of the vaccine – phase 3 – on a number of 20,000 participants.

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