Wednesday, February 24, 2021

What decides whether a corona course will be bad


What decides whether a corona course will be difficult

Severe courses are related to genes. Image: keystone

Hospitalized Covid-19 patients show a certain gene variation much more often than people with mild courses. In particular, those affected with a partial or total lack of the NKG2C receptor fall seriously ill, the MedUni Vienna reported on Monday.

“This part of the immune response could therefore also be an important target for drugs that could help prevent severe Covid 19 diseases,” said virologist Elisabeth Puchhammer-Stöckl.

The antiviral immune response by natural killer cells (NK cells) is an important step in combating virus replication in the early stages of infection. These killer cells have special, activating receptors on their surface. These include the NKG2C receptor, which communicates with an infected cell via one of its specific surface structures, the HLA-E. This interaction leads to the destruction of the virus-infected cells.

Severe courses in the absence of a receptor

Around four percent of the population lacks the activating receptor NKG2C due to a gene variation, while around 30 percent of the population only partially has the receptor. A research group from the MedUni Center for Virology, headed by Puchhammer-Stöckl, has now shown that especially people with a partial or complete absence of the NKG2C receptor develop severe courses.

“The lack of the receptor was particularly common in patients who had to be treated with Covid-19 in intensive care units, regardless of age or gender. Genetic variations in the HLA-E of the infected cell were also associated with the severity of the disease, albeit to a lesser extent, ”explained Puchhammer-Stöckl. The current study, which recently appeared in the journal “Genetics in Medicine”, therefore shows the great importance of the NK cell response in the fight against SARS-CoV-2 infection.

(aeg / sda / apa)

THANK YOU FOR THE ♥

Would you like to support watson and journalism? Learn more

(You will be redirected to complete the payment)

5 CHF

15 CHF

25 CHF

Another

The coronavirus in Switzerland – a chronology

World of watson: Päärli-Lockdown – der Film

You might also be interested in:

Subscribe to our newsletter

Liveticker

Brits want to open everything by the end of June ++ 2449 new corona cases, 10 dead

Link to the article



#decides #corona #bad

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Hot Topics

The European Agency and the WHO also gave a recommendation for the elderly – the Society

The first quantities of Astrazeneka's vaccine, 150,000 doses, arrived in Serbia over the weekend, and Marija Gnjatović from the Institute for the Application...

The “SEHA” Radiology Conference explores the latest innovations and technological developments – UAE – News and Reports

The Abu Dhabi Health Services Company, "SEHA", organized the 10th session of the "SEHA" International Conference on Radiology recently, which comes in line...

Suspect confesses to killing critical Maltese journalist in 2017 | NOW

A suspect in the killing of Maltese anti-corruption journalist Daphne Caruana...

Related Articles

The European Agency and the WHO also gave a recommendation for the elderly – the Society

The first quantities of Astrazeneka's vaccine, 150,000 doses, arrived in Serbia over the weekend, and Marija Gnjatović from the Institute for the Application...

The “SEHA” Radiology Conference explores the latest innovations and technological developments – UAE – News and Reports

The Abu Dhabi Health Services Company, "SEHA", organized the 10th session of the "SEHA" International Conference on Radiology recently, which comes in line...

Suspect confesses to killing critical Maltese journalist in 2017 | NOW

A suspect in the killing of Maltese anti-corruption journalist Daphne Caruana...